Day: November 9, 2022

With this latest expansion, Medison’s global footprint is now extended across Israel, Central and Eastern Europe, Canada, Asia-Pacific and Latin America, offering patients in international markets improved access to highly innovative therapies.

PETACH TIKVAH, Israel, Nov. 9, 2022 /PRNewswire/ — Medison Pharma (“Medison”), a global pharma company focused on providing access to highly innovative therapies to patients in international markets, today announced the addition of South and Central America and the Caribbean markets (“Latin America”) to its multi-territorial agreement with Immunocore Holdings plc (Nasdaq: IMCR) (“Immunocore”), a commercial-stage biotechnology company pioneering the development of a novel class of T cell receptor (TCR) bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease.

“The expansion of our partnership with Immunocore into LATAM is a significant milestone in building our unified commercial platform in all international markets,” says Meir Jakobsohn, Founder and CEO of Medison. “This in turn will allow us to fulfil our vision, ensuring that every patient in need will have fast access to highly innovative therapies in a wide range of international markets.”

“Our multi-regional platform makes us the partner-of-choice for emerging biotech companies seeking to make their innovative products available in international markets for the benefit of patients suffering from severe conditions”, adds Gil Gurfinkel, VP Corporate Development at Medison “and the extension of Medison’s multi-territorial agreement with Immunocore and expansion to Latin America, allows for a unique pairing between Immunocore’s novel therapy and Medison’s ability to commercialize and provide access to highly innovative therapies in international markets. In this case, offering patients in Latin America hope in the form of a treatment for this rare and aggressive form of melanoma that affects the eye.”

Immunocore’s KIMMTRAK® (tebentafusp-tebn), has been approved by the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), Australia Therapeutic Goods Administration (TGA) and Health Canada, and is the first and only treatment approved for patients with unresectable or metastatic uveal melanoma.”

With this latest growth, Medison increases its commercial presence across Israel, Central and Eastern Europe, Canada, Asia-Pacific, South and Central America and the Caribbean countries. Medison is hiring across all markets and in key functions. To learn more about open roles, visit: https://www.medisonpharma.com/careers/

About Medison Pharma

Medison is a global pharma company focused on providing access to highly innovative therapies to patients in international markets.

Medison is the first to create an international commercialization platform for highly innovative therapies, helping to save and improve lives by making the best available novel treatments accessible to patients in international markets. Medison has a track record of multi-territorial partnerships with leading pharmaceutical and biotech companies seeking to expand their global reach.

To learn more visit www.medisonpharma.com

About KIMMTRAK^® (tebentafusp-tebn)

KIMMTRAK is a novel bispecific protein comprised of a soluble T cell receptor fused to an anti-CD3 immune-effector function. KIMMTRAK specifically targets gp100, a lineage antigen expressed in melanocytes and melanoma. This is the first molecule developed using Immunocore’s ImmTAC technology platform designed to redirect and activate T cells to recognise and kill tumour cells. KIMMTRAK has been granted Breakthrough Therapy Designation, Fast Track designation and orphan drug designation by the FDA in the United States, Accelerated Assessment by the EMA, and Promising Innovative Medicine (PIM) designation under the UK Early Access to Medicines Scheme for metastatic uveal melanoma. KIMMTRAK is currently approved in 31 countries, including the United States and European Union.

USAGE

KIMMTRAK is a prescription medicine used to treat HLA-A*02:01–positive adults with uveal melanoma that cannot be removed by surgery or has spread.

IMPORTANT U.S. SAFETY INFORMATION Regarding FDA Approval

Cytokine Release Syndrome (CRS), which may be serious or life-threatening, occurred in patients receiving KIMMTRAK. Monitor for at least 16 hours following first three infusions and then as clinically indicated. Manifestations of CRS may include fever, hypotension, hypoxia, chills, nausea, vomiting, rash, elevated transaminases, fatigue, and headache. CRS occurred in 89% of patients who received KIMMTRAK with 0.8% being grade 3 or 4. Ensure immediate access to medications and resuscitative equipment to manage CRS. Ensure patients are euvolemic prior to initiating the infusions. Closely monitor patients for signs or symptoms of CRS following infusions of KIMMTRAK. Monitor fluid status, vital signs, and oxygenation level and provide appropriate therapy. Withhold or discontinue KIMMTRAK depending on persistence and severity of CRS.

Skin Reactions

Skin reactions, including rash, pruritus, and cutaneous edema occurred in 91% of patients treated with KIMMTRAK. Monitor patients for skin reactions. If skin reactions occur, treat with antihistamine and topical or systemic steroids based on persistence and severity of symptoms. Withhold or permanently discontinue KIMMTRAK depending on the severity of skin reactions.

Elevated Liver Enzymes

Elevations in liver enzymes occurred in 65% of patients treated with KIMMTRAK. Monitor alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total blood bilirubin prior to the start of and during treatment with KIMMTRAK. Withhold KIMMTRAK according to severity.

Embryo-Fetal Toxicity

KIMMTRAK may cause fetal harm. Advise pregnant patients of potential risk to the fetus and patients of reproductive potential to use effective contraception during treatment with KIMMTRAK and 1 week after the last dose.

The most common adverse reactions (≥30%) in patients who received KIMMTRAK were cytokine release syndrome, rash, pyrexia, pruritus, fatigue, nausea, chills, abdominal pain, edema, hypotension, dry skin, headache, and vomiting. The most common (≥50%) laboratory abnormalities were decreased lymphocyte count, increased creatinine, increased glucose, increased AST, increased ALT, decreased hemoglobin, and decreased phosphate.

Please see full Prescribing Information, including BOXED WARNING for CRS.

Medison Contact

Inbal Chen, Corporate Communications
T: +972-54-4400784
E: inbalc@medisonpharma.com

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The global place branding advisor today announced the world’s 100 top-performing cities in their annual World’s Best Cities Report.

NEW YORK, Nov. 9, 2022 /PRNewswire/ — Resonance is a leading advisor in tourism, real estate and economic development, and its Best Cities rankings quantify and benchmark the relative quality of place, reputation and competitive identity for the world’s principal cities with metropolitan populations of 1 million+. They are lauded as the world’s most thorough city ranking, based on original methodology that analyzes key statistics as well as user-generated reviews and online activity in channels such as Google, Facebook and Instagram.

Access the 2023 World’s Best Cities Report and all 100 city profiles at WorldsBestCities.com.

Learn more about Resonance Consultancy at ResonanceCo.com.

“The World’s Best Cities rankings benchmark the overall performance of more than 250 cities around the world based on a wide variety of measures in order to identify the top 100 places to live, visit and invest,” says Resonance President & CEO Chris Fair.

The overall Best Cities rankings are determined by analyzing the performance of each city for a wide range of factors that have historically shown positive correlations with attracting employment, investment and/or visitors to cities.

Based on each city’s performance in the 24 factors analyzed, these are the World’s Best Cities for 2023:

Honorary World’s Best City: Kyiv, Ukraine

1. London, England
2. Paris, France
3. New York City, USA
4. Tokyo, Japan
5. Dubai, United Arab Emirates
6. Barcelona, Spain
7. Rome, Italy
8. Madrid, Spain
9. Singapore, Republic of Singapore
10. Amsterdam, Netherlands

The full ranking is available at WorldsBestCities.com.

Resonance is a global consultancy of strategic and creative place makers. As leading advisors in real estate, tourism and economic development, Resonance combines expertise in research, strategy, branding and communications to make destinations, cities and developments more valuable and more vibrant. ResonanceCo.com

Best Cities is the home of Resonance’s exclusive ranking of the world’s top urban destinations. The data is used by leading news outlets and Bloomberg calls it “The most comprehensive study of its kind; it identifies cities that are most desirable for locals, visitors, and businesspeople alike, rather than simply looking at livability or tourism appeal.” WorldsBestCities.com | #BestCities

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SHENZHEN, China, Nov. 9, 2022 /PRNewswire/ — ZTE Corporation (0763.HK / 000063.SZ), a global leading provider of information and communication technology solutions, today has kicked off the 5G Summit and User Congress 2022 at Lake Maggiore in Stresa, Italy.

ZTE holds this 5G Summit and User Congress with the theme of “Inspire the Digital Transformation” from 8-9 November, 2022. Various thought leaders, industry partners, leading analysts from GSMA, Intel, CCS, IGF, 3GPP and Global Data, top-tier operators and many others join the event, and will share their key insights. The 2-day event has invited over 300 attendees from more than 70 companies, while over 50 guests will speak on 5G cases, successful ecosystem, digital transformation, B5G, and green sustainable topics.

“In the future, digital world and real world will interact with each other on a larger scale, breaking the dimensional space, and gradually evolving into a new era of deep and seamless connection,” highlighted Mr. Xiao Ming, Senior Vice President of ZTE. “Every step we take today is to faithfully and firmly measure the real world, and to open up and reconstruct new boundaries of the virtual world.”

Digital Transformation is no longer just a simple innovation, and it has become an intelligent connection of different services and industry verticals.

“One of the key missions of 5G in the coming years is to empower digital transformation across all sectors. Last year saw 5G expand commercially into vertical, already exploring economies of scale,” said John Hoffman, CEO of GSMA Ltd. “However, to achieve these economies, industries need to explore many different application scenarios to move 5G from an optional to a must-have technology.”

“If we want to build stronger businesses and communities, and achieve the sustainable development goals, we simply cannot afford to leave anyone behind. Mobile operators play a key role in the tech innovation ecosystem. Operators can mitigate the route-to-market challenges by providing the platform, customer relationship, and resources to drive their mobile innovation to scale,” noted Lara Dewar, CMO of GSMA Ltd.

With all-scenarios, applications, and innovative connection technologies as the foundation, ZTE has integrated smart digitalization into all aspects of life, such as smart manufacturing, port, medicine, home, etc., and is also effectively providing underlying technologies to support the digital transformation of industries and society. Business models, technologies, and customer needs are changing at a break-neck pace. Therefore, a collaborative ecosystem helps telco industries not only survive but also thrive in such a demanding era. During the event, ZTE will be further showcasing its cutting-edge technologies and solutions, and launch the B5G Technology Whitepaper in partnership with GSMA.

The successful vertical case demonstration not only hammers on the reality in the 5G era but also demonstrates how the industry can monetize these applications and mass scale. Also, ZTE experts and leaders showcase the network’s success in different regions across the globe. The launch of Mini 5GC depicts that ZTE products are the first in the market that have already been adopted by operators.

Moving forward, ZTE, with the commitment to its vision and mission, that is, “to enable connectivity and trust everywhere” and “to connect the world with continuous innovation for a better future”, will further boost digital transformation.

Media Contacts:
Margaret Ma
ZTE Corporation
Tel: +86 755 26775189
Email: ma.gaili@zte.com.cn